In April 2012, Blake and co-star Andy Lee won a Logie Award for their television program Hamish and Andy's Gap Year.
After a gap year, Blake enrolled at the University of Melbourne in a Science/Commerce double degree.
"I'm interested in artificial intelligence and computer science. However, a few weeks into the semester, he met Andy Lee: "That was the turning point.
The wheels quickly fell off my academic career." Blake eventually dropped out of university to pursue a career in comedy alongside Lee.
Hamish Donald Blake (born 11 December 1981) is an Australian comedian, actor, and author from Melbourne.
Since 2003, he has worked with Andy Lee as part of the comedy duo Hamish and Andy.
The pair have performed live and on television and radio, most notably with their drive-time radio program Hamish & Andy.
As a solo performer, Blake has appeared on various Australian television programs, including the Melbourne International Comedy Festival's televised 2008 Great Debate, and has been a regular guest on Spicks and Specks, Rove and Thank God You're Here.
His parents, Noel and Kerry, separated when Blake was 17, with his father eventually remarrying.
As a child, Blake says he was a fan of British comedy such as Monty Python, Fawlty Towers and Blackadder; as a teenager he "worshipped" comedians Tony Martin and Mick Molloy.
Blake was a member of the National Boys Choir of Australia during the late 1980s.
He attended primary school at Glen Waverley South Primary, high school at Caulfield Grammar School and later at St Leonard's College, graduating in 1999.